Remove each location from the game. (Investigators are not defeated during this process. Other enemies and attachments at those locations are discarded, and concealed mini-cards are set aside.)

Put The Knotted Tower, Gravity-Defying Climb, and The Towering Vertex locations into play in a straight vertical line, with The Towering Vertex at the top and The Knotted Tower at the bottom. Take the top 3 locations in the Otherworld deck and place them in the shadows, arranged in a line from left to right. Take the 3 City of Remnants mini-cards, shuffle them facedown, and arrange them around The Knotted Tower as follows: One to its left, one to its right, and one below.

Place each investigator at The Knotted Tower and The Red-Gloved Man enemy at the Towering Vertex. Remove the encounter deck and encounter discard pile from the game, replacing them with the second encounter deck.