I posted this in a reply, but I've been playing it with William Yorick in Edge of the Earth, running Short Supply Charisma and In the Thick of It. From the start that meant that my chances of getting at least 2 dogs up for +2 to hit, 2 damage (or 2 moves) were pretty danged good, and turns out that was right. In Yorick these are great. You draw a dog in upkeep? Commit it for an icon on your next fight test, defeats the enemy and play it from your discard pile. Or maybe there's a dog or two already in there thanks to Short Supply. Honestly to have these dogs as a baseline for moving and attacking, while adding in and out other assets as needed - these babies are perfect for Yorick, and relatively easy to get into play. You do have to watch your resources, but even with an item-heavy build (that Willie likes), 2 copies of Schoffner's Catalogue and 2 copies of good ol' Emergency Cache, you're in pretty good shape!
Chirping in here, standing on the backs of others to shine a spotlight on this encounter card. More specifically, why the designers decided to give the official "Mechanic" in the game, Daniela Reyes, an Intellect of 1. The character who's supposed to be the best with machines in the whole game is the worst at fixing a broken engine. I know it's Arkham, but jeez. This test is gonna be house ruled when it comes to Daniela more often than not. Maybe it's a Will test for her, or I'd just give her a token pull and she succeeds unless it's an autofail.
It is but a short step between the time this card hits you and when your permanent stay at an asylum begins. You better hope you have a Ward of Protection or Forewarned in your hand. Not only will this cost you two actions but you'll have to pay actions and resources to put out any hand and body items that were forced back in your hand.
Many characters can start a game with 2 classes only with their permanents. But if you plan your assets accordingly (for example if you are going rich Unscrupulous Loan will cover ), this card replace way more effectively Hot Streak (even it's upgraded version because it's fast and free, meaning you can play it whenever you want).
I think Rogues could be the best class to go down the Synergy road, because you can Double, Double Call for Backup for maximum efficiency.
Great card for a supporter to run when you have Dexter Drake in your team. It essentially grants him a free resource and play action. Additionally you might use it to boost Dexter's main ability by committing this card for the double pips.